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DIDS (4,4′-Diisothiocyanatostilbene-2,2′-disulfonate) directly inhibits caspase activity in HeLa cell lysates.

Apoptosis is an important mechanism of cell demise in multicellular organisms and Cl(-) transport has an important role in the progression of the apoptotic volume decrease (AVD). DIDS (4,4′-Diisothiocyanatostilbene-2,2′-disulfonate) is one of the most commonly used Cl(-) transport inhibitors that eliminates or reduces different apoptotic hallmarks such as AVD, caspase-3 activity and DNA fragmentation. DIDS …

DIDS (4,4′-Diisothiocyanatostilbene-2,2′-disulfonate) directly inhibits caspase activity in HeLa cell lysates. Read More »

The vermiform appendix impacts the risk of developing Parkinson’s disease.

The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed …

The vermiform appendix impacts the risk of developing Parkinson’s disease. Read More »

High-Density Single Nucleotide Polymorphisms Genetic Map Construction and Quantitative Trait Locus Mapping of Color-Related Traits of Purple Sweet Potato [ Ipomoea batatas (L.) Lam.] Download PDF TRANSLATE Journal: Frontiers in Plant ScienceJanuary/24/2022

Flesh color (FC), skin color (SC), and anthocyanin content (AC) are three important traits being used for commodity evaluation in purple-fleshed sweet potato. However, to date, only a few reports are available on the inheritance of these traits. In this study, we used a biparental mapping population of 274 F1 progeny generated from a cross …

High-Density Single Nucleotide Polymorphisms Genetic Map Construction and Quantitative Trait Locus Mapping of Color-Related Traits of Purple Sweet Potato [ Ipomoea batatas (L.) Lam.] Download PDF TRANSLATE Journal: Frontiers in Plant ScienceJanuary/24/2022 Read More »

Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa16 cells.

BACKGROUND The tumor-draining lymph node (TDLN) is the critical and initial site of the immune decision made between activation and tolerance to tumor antigens. Tumor-reactive lymphadenopathy in TDLN has been observed for decades, but the profiles of immune regulation in these nodes remain unclear. METHODS Both regulatory T cells (Tregs) and effector T cells were …

Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa16 cells. Read More »

Steroid Sulfatase in the Mouse NIH3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids

Steroid hormones often circulate in the blood as inactive sulfated forms, such as estrone sulfate and dehydroepiandrosterone sulfate. The enzyme steroid sulfatase (STS) converts these steroids into active forms, mainly estrogens, in peripheral tissues. We have previously characterized STS activity in human and mouse breast and bone tissues, and we have shown that STS can …

Steroid Sulfatase in the Mouse NIH3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids Read More »

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