Hymenoptera

The vermiform appendix impacts the risk of developing Parkinson’s disease.

The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated α-synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed …

The vermiform appendix impacts the risk of developing Parkinson’s disease. Read More »

Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa16 cells.

BACKGROUND The tumor-draining lymph node (TDLN) is the critical and initial site of the immune decision made between activation and tolerance to tumor antigens. Tumor-reactive lymphadenopathy in TDLN has been observed for decades, but the profiles of immune regulation in these nodes remain unclear. METHODS Both regulatory T cells (Tregs) and effector T cells were …

Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa16 cells. Read More »

Steroid Sulfatase in the Mouse NIH3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids

Steroid hormones often circulate in the blood as inactive sulfated forms, such as estrone sulfate and dehydroepiandrosterone sulfate. The enzyme steroid sulfatase (STS) converts these steroids into active forms, mainly estrogens, in peripheral tissues. We have previously characterized STS activity in human and mouse breast and bone tissues, and we have shown that STS can …

Steroid Sulfatase in the Mouse NIH3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids Read More »

Elucidating the Innate Immunological Effects of Mild Magnetic Hyperthermia on U87 Human Glioblastoma Cells: An In Vitro Study

Cancer immunotherapies have been approved as standard second-line or in some cases even as first-line treatment for a wide range of cancers. However, immunotherapy has not shown clinically relevant success in glioblastoma (GBM). This is principally due to the brain’s “immune-privileged” status and the peculiar tumor microenvironment (TME) of GBM characterized by a lack of …

Elucidating the Innate Immunological Effects of Mild Magnetic Hyperthermia on U87 Human Glioblastoma Cells: An In Vitro Study Read More »

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