Steroid Sulfatase in the Mouse NIH–3T3 Fibroblast Cell Line: Characterization, and Downregulation by Glucocorticoids
Steroid hormones often circulate in the blood as inactive sulfated forms, such as estrone sulfate and dehydroepiandrosterone sulfate. The enzyme steroid sulfatase (STS) converts these steroids into active forms, mainly estrogens, in peripheral tissues. We have previously characterized STS activity in human and mouse breast and bone tissues, and we have shown that STS can …