Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa1–6 cells.
BACKGROUND The tumor-draining lymph node (TDLN) is the critical and initial site of the immune decision made between activation and tolerance to tumor antigens. Tumor-reactive lymphadenopathy in TDLN has been observed for decades, but the profiles of immune regulation in these nodes remain unclear. METHODS Both regulatory T cells (Tregs) and effector T cells were …