To Order: patrick@cotinis.com
Polyclonal FOXO4 Antibody |
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| APR06642G | Leading Biology | 0.1 mg | EUR 659 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 . This antibody is tested and proven to work in the following applications: |
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Polyclonal FOXO4 Antibody |
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| APR06643G | Leading Biology | 0.1 mg | EUR 659 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 . This antibody is tested and proven to work in the following applications: |
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FoxO4 Polyclonal Antibody |
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| ABP58590-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 from Human. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 protein at amino acid sequence of 170-200 |
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FoxO4 Polyclonal Antibody |
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| ABP58590-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 from Human. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 protein at amino acid sequence of 170-200 |
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FoxO4 Polyclonal Antibody |
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| ABP58590-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 from Human. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 protein at amino acid sequence of 170-200 |
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FoxO4 Polyclonal Antibody |
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| ABP51368-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse, Monkey. This FoxO4 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of T451 |
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FoxO4 Polyclonal Antibody |
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| ABP51368-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse, Monkey. This FoxO4 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of T451 |
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FoxO4 Polyclonal Antibody |
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| ABP51368-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse, Monkey. This FoxO4 antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of T451 |
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FoxO4 Polyclonal Antibody |
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| ABP51369-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S197 |
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FoxO4 Polyclonal Antibody |
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| ABP51369-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S197 |
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FoxO4 Polyclonal Antibody |
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| ABP51369-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S197 |
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FoxO4 Polyclonal Antibody |
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| ABP55260-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S262 |
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FoxO4 Polyclonal Antibody |
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| ABP55260-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S262 |
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FoxO4 Polyclonal Antibody |
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| ABP55260-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 from Human, Mouse. This FoxO4 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the non-phosphorylation site of S262 |
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FOXO4 Rabbit pAb |
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| A3307-100ul | Abclonal | 100 ul | EUR 308 |
FOXO4 Rabbit pAb |
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| A3307-200ul | Abclonal | 200 ul | EUR 459 |
FOXO4 Rabbit pAb |
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| A3307-20ul | Abclonal | 20 ul | EUR 183 |
FOXO4 Rabbit pAb |
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| A3307-50ul | Abclonal | 50 ul | EUR 223 |
Polyclonal FOXO4 Antibody (Center) |
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| APR04859G | Leading Biology | 0.1ml | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 (Center). This antibody is tested and proven to work in the following applications: |
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Rabbit Anti-Human FOXO4 Polyclonal Antibody, Phospho-Ser197 |
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| CPB-696RH | Creative Diagnostics | 100 ul | EUR 559 |
FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| ES8622-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (Acetyl Lys189) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| ES8622-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (Acetyl Lys189) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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FoxO4 (phospho Thr451) Polyclonal Antibody |
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| ES6257-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (phospho Thr451) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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FoxO4 (phospho Thr451) Polyclonal Antibody |
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| ES6257-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (phospho Thr451) from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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FoxO4 (phospho Ser262) Polyclonal Antibody |
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| ES6258-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (phospho Ser262) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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FoxO4 (phospho Ser262) Polyclonal Antibody |
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| ES6258-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against FoxO4 (phospho Ser262) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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FOXO4 (phospho Ser197) Polyclonal Antibody |
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| ES1316-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against FOXO4 (phospho Ser197) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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FOXO4 (phospho Ser197) Polyclonal Antibody |
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| ES1316-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against FOXO4 (phospho Ser197) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Polyclonal FOXO4 Antibody (C-term) |
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| APR04776G | Leading Biology | 0.1ml | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 (C-term). This antibody is tested and proven to work in the following applications: |
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Polyclonal FOXO4 antibody - middle region |
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| APR01891G | Leading Biology | 0.05mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 - middle region. This antibody is tested and proven to work in the following applications: |
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Polyclonal FOXO4 / AFX1 Antibody (Ser197) |
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| APR02403G | Leading Biology | 0.05mg | EUR 484 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FOXO4 / AFX1 (Ser197). This antibody is tested and proven to work in the following applications: |
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FoxO4 (Phospho-Ser197) Polyclonal Antibody |
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| 12200-100ul | SAB | 100ul | EUR 252 |
FoxO4 (Phospho-Ser197) Polyclonal Antibody |
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| 12200-50ul | SAB | 50ul | EUR 187 |
FoxO1/FoxO3a/FoxO4 Polyclonal Antibody |
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| 30243-100ul | SAB | 100ul | EUR 252 |
FoxO1/FoxO3a/FoxO4 Polyclonal Antibody |
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| 30243-50ul | SAB | 50ul | EUR 187 |
FoxO4 (phospho Ser197) Polyclonal Antibody |
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| ABP50317-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser197) from Human, Mouse. This FoxO4 phospho Ser197) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S197 |
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FoxO4 (phospho Ser197) Polyclonal Antibody |
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| ABP50317-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser197) from Human, Mouse. This FoxO4 phospho Ser197) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S197 |
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FoxO4 (phospho Ser197) Polyclonal Antibody |
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| ABP50317-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser197) from Human, Mouse. This FoxO4 phospho Ser197) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S197 |
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FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| ABP58589-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 Acetyl Lys189) from Human. This FoxO4 Acetyl Lys189) antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 (Acetyl Lys189) protein at amino acid sequence of 189 |
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FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| ABP58589-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 Acetyl Lys189) from Human. This FoxO4 Acetyl Lys189) antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 (Acetyl Lys189) protein at amino acid sequence of 189 |
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FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| ABP58589-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 Acetyl Lys189) from Human. This FoxO4 Acetyl Lys189) antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FoxO4 (Acetyl Lys189) protein at amino acid sequence of 189 |
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FoxO4 (phospho Thr451) Polyclonal Antibody |
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| ABP55258-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Thr451) from Human, Mouse. This FoxO4 phospho Thr451) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of T451 |
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FoxO4 (phospho Thr451) Polyclonal Antibody |
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| ABP55258-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Thr451) from Human, Mouse. This FoxO4 phospho Thr451) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of T451 |
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FoxO4 (phospho Thr451) Polyclonal Antibody |
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| ABP55258-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Thr451) from Human, Mouse. This FoxO4 phospho Thr451) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of T451 |
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FoxO4 (phospho Ser262) Polyclonal Antibody |
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| ABP55259-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser262) from Human, Mouse. This FoxO4 phospho Ser262) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S262 |
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FoxO4 (phospho Ser262) Polyclonal Antibody |
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| ABP55259-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser262) from Human, Mouse. This FoxO4 phospho Ser262) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S262 |
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FoxO4 (phospho Ser262) Polyclonal Antibody |
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| ABP55259-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of FoxO4 phospho Ser262) from Human, Mouse. This FoxO4 phospho Ser262) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human FoxO4 around the phosphorylation site of S262 |
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FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| HW175-100ul | SAB | 100ul | EUR 252 |
FoxO4 (Acetyl Lys189) Polyclonal Antibody |
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| HW175-50ul | SAB | 50ul | EUR 187 |
FOXO4 Antibody |
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| 1-CSB-PA277767 | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000 |
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FOXO4 Antibody |
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| 1-CSB-PA002575 | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human, Mouse, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000 |
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FOXO4 Antibody |
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| 1-CSB-PA002576 | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
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FOXO4 Antibody |
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| 1-CSB-PA008839GA01HU | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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FOXO4 Antibody |
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| 1-CSB-PA008839OA01HU | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
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FOXO4 Antibody |
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| 1-CSB-PA010207 | Cusabio |
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Description: A polyclonal antibody against FOXO4. Recognizes FOXO4 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
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FOXO4 Antibody |
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| 25139-100ul | SAB | 100ul | EUR 390 |
FOXO4 Antibody |
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| 25140-100ul | SAB | 100ul | EUR 390 |
FOXO4 Antibody |
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| 43669-100ul | SAB | 100ul | EUR 252 |
FOXO4 Antibody |
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| 49179-100ul | SAB | 100ul | EUR 333 |
FOXO4 Antibody |
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| 49179-50ul | SAB | 50ul | EUR 239 |
FOXO4 Antibody |
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| 49279-100ul | SAB | 100ul | EUR 333 |
FOXO4 Antibody |
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| 49279-50ul | SAB | 50ul | EUR 239 |
FOXO4 Antibody |
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| AF6369 | Affbiotech | 200ul | EUR 304 |
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Description: FOXO4 Antibody detects endogenous levels of total FOXO4. |
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FoxO4 Antibody |
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| AF7841 | Affbiotech | 200ul | EUR 376 |
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Description: FoxO4 Antibody detects endogenous levels of FoxO4. |
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FOXO4 Antibody |
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| ABF6369 | Lifescience Market | 100 ug | EUR 438 |
FOXO4 antibody |
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| 70R-17348 | Fitzgerald | 50 ul | EUR 435 |
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Description: Rabbit polyclonal FOXO4 antibody |
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FOXO4 antibody |
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| 70R-36190 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal FOXO4 antibody |
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FOXO4 antibody |
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| 70R-50062 | Fitzgerald | 100 ul | EUR 287 |
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Description: Purified Polyclonal FOXO4 antibody |
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FOXO4 antibody |
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| 70R-50063 | Fitzgerald | 100 ul | EUR 287 |
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Description: Purified Polyclonal FOXO4 antibody |
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FOXO4 antibody |
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| 70R-50064 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal FOXO4 antibody |
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FOXO4 Antibody |
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| 5815-002mg | ProSci | 0.02 mg | EUR 171.82 |
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Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity. |
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FOXO4 Antibody |
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| 5815-01mg | ProSci | 0.1 mg | EUR 436.42 |
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Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity. |
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FOXO4 Antibody |
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| 5817-002mg | ProSci | 0.02 mg | EUR 171.82 |
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Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity. |
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FOXO4 Antibody |
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| 5817-01mg | ProSci | 0.1 mg | EUR 436.42 |
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Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity. |
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